Food Affects Mood

No one likes to hear the old adage “you are what you eat”, but food affects mood, especially for children. Children in general can be very sensitive to foods, resulting in mood changes very quickly. For instance, too much salt and sugar can make a child hyperactive shifting the nervous system into fight or flight.

Too many carbohydrates can increase yeast and Candida, which can cause non-compliant difficult behaviors, hyperactivity and even some aggression. Too many chemicals, dyes, phenols, glutamates and preservatives in foods can cause mood and behavioral changes.

Children with autism, ADHD, mood disorders and other chronic health conditions are even more sensitive to foods than neurotypical children. These children can develop imbalances in neurotransmitters, food sensitivities and intolerances, hypoglycemia, brain allergies and excitotoxicity.

All of these imbalances can predispose the child to food and mood issues because of heightened sensitivity to foods, Leaky Gut Syndrome and the gut/brain connection.

Imbalances in Neurotransmitters (NTs)

Neurotransmitters are the chemical messengers in the brain that tell the body what to do. There are excitatory neurotransmitters and inhibitory (calming) neurotransmitters. Some neurotransmitters like serotonin, dopamine and norepinephrine are made in the body from certain foods that we eat.

Tryptophan, for example, is an amino acid found in protein that converts into serotonin which is known as a “calming” neurotransmitter. Tyrosine, on the other hand, is an amino acid that converts into dopamine, which can cause cravings and addictions when elevated, and norepinephrine, which can cause anxiety and stress when elevated.

Foods, especially sugar and carbohydrates, can cause chemical imbalances in neurotransmitters in the brain which have a profound effect on mood and behaviors. This is particularly prevalent with children with neurological disorders who have Leaky Gut Syndrome, which affects the gut/brain axis triggering moods and behaviors.


Imbalances in neurotransmitters, whether high or low, can affect the mood and behaviors of a child. Serotonin, known as the “happy hormone”, regulates and stabilizes:

  • Mood
  • Sleep
  • Appetite
  • Anxiety
  • Impulse control
  • Cognition

Serotonin is found in large quantities in the gastrointestinal system due to the digestive stimulatory properties, so healing the gastrointestinal tract is an important factor in increasing serotonin levels.


Dopamine and norepinephrine are catecholamines, both hormones and neurotransmitters, which play an important role in mood and behaviors. Too much dopamine can result in intense psychotic anxiety, inappropriate thinking process and even psychosis. Norepinephrine is the stress hormone that controls attention and response actions. If norepinephrine is too high, it can also cause manic episodes.

Excitatory Neurotransmitters

Glutamate, glutamic acid and glutamine are all excitatory neurotransmitters. Too many glutamates produce excitotoxicity, causing nerve damage or cell death; the result of this triggers inflammation.

Excess glutamates cause hyperactivity, mood swings, seizures, insomnia and aggressive behaviors. Excitotoxins such as glutamate and aspartate (aspartame) are amino acids that can excite and damage neurons to the point of cell death. The most commonly known glutamate is MSG, monosodium glutamate. However, there are many sources of glutamate in foods, such as:

  • Gluten
  • Casein
  • Salicylates
  • Amines
  • Benzoates
  • Preservatives
  • Nitrates
  • Tartrazine
  • Food dyes
  • Brewer’s
  • Hydrolyzed yeast

For a more complete list of glutamate in food that provoke moods, please see Dr. Amy Yasko’s list here.

In addition, Russell Blaylock MD’s book Excitoxins: The Taste That Kills explains the affect that food has on the brain causing excitotoxicity (cell death) and triggering mood and behaviors. Excitotoxicity can cause:

  • Hyperactivity
  • Seizures
  • Insomnia
  • Self-stimulatory behaviors
  • Fight or flight
  • Anxiety
  • Fears
  • Lack of focus and concentration
  • Self-injurious behaviors

Inhibitatory Neurotransmitters

GABA, an inhibitory neurotransmitter, calms behaviors, anxiety and aggression and regulates mood. Too many glutamates can decrease GABA levels. L-taurine and L-tryptophan both have a calming effect on behaviors.

Other Neurotransmitters

L-phenylalanine and L-tyrosine can improve thyroid functioning which improves energy levels and mood.


Hypoglycemia is a blood sugar decline that occurs when glucose levels drop, causing energy levels to drop. An increase in blood sugar levels from eating sugar or carbohydrates can increase the neurotransmitter dopamine which triggers addictive behaviors and cravings. When this happens, the body craves something sweet to boost energy and then initiates a vicious cycle of sugar highs and lows.

A diet high in sugar and carbohydrates such as potato chips, donuts, margarine, French fries, soda, snack peanuts, bagels, baked goods, sugar free drink mixes, ketchup, fast food, and food additives can trigger symptoms of:

  • Mood swings
  • Hyperactivity
  • Self-stimulatory behaviors
  • Anger
  • Meltdowns
  • Confusion
  • Depression
  • Irritability
  • Anxiety
  • Aggression

Food Sensitivities and Intolerances

Many children today experience food sensitivities and intolerances that are known to have adverse effects on their mood and behaviors. Unfortunately, when parents see unwanted behaviors, depression or mood swings in their children, their pediatrician may want to prescribe medication instead of examining the child’s diet and looking for the triggers that are creating food sensitivities and intolerances.

Food sensitivities and intolerances in children can trigger:

  • Anxiety
  • Moods swings
  • Meltdowns
  • Depression
  • Self-stimulatory behaviors
  • Hyperactivity
  • Non-compliant behaviors
  • Aggression
  • Inability to sleep

Some foods may cause children to become picky eaters and prone to craving foods their bodies are intolerant to, such as:

  • Refined sugar
  • White flour
  • Refined carbohydrates
  • Dairy (milk)
  • Gluten from foods such as wheat, barley and rye
  • Eggs
  • Soy
  • MSG
  • Yeast-containing foods
  • Food dyes
  • Aspartame
  • Glutamates
  • Casein
  • Nuts
  • Peanuts
  • Garlic
  • Shellfish
  • Corn

Children can develop picky eating due to the chronic inflammatory response from the gastrointestinal system (Leaky Gut Syndrome) which exacerbates their symptoms and creates a vicious cycle unless the foods to which children have intolerances are removed.

Brain Allergies

Brain allergies can upset hormone levels and neurotransmitters. Foods can create psychological, emotional and neurological symptoms in a child. Gluten and casein can be contributing factors to triggering mental health conditions. Researchers have done studies on the effects of removing gluten from the diet from a teen with a schizophrenic diagnosis and the results showed the disappearance of psychiatric symptoms. Casein studies have also been done with bipolar patients who removed casein from their diet and reduced symptoms of mania and psychosis.

Sources & References

Adams, J.B., et al. Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial. Nutrients. 2018 Mar 17;10(3).

Adams, J.B., et al. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutr Metab (Lond) 2011 Jun 8;8(1):34.

Aucoin, M., et al. Major Depressive Disorder and Food Hypersensitivity: A Case Report. Neuropsychobiology. 2019 Oct 10:1-7.

Blaylock, R.L. A possible central mechanism in autism spectrum disorders, part 1. Altern Ther Health Med. 2008 Nov-Dec;14(6):46-53.

Blaylock, R.L. A possible central mechanism in autism spectrum disorders, part 2: immunoexcitotoxicity. Altern Ther Health Med. 2009 Jan-Feb;15(1):60-7.

Blaylock, R.L. A possible central mechanism in autism spectrum disorders, part 3: the role of excitotoxin food additives and the synergistic effects of other environmental toxins. Altern Ther Health Med. 2009 Mar-Apr;15(2):56-60.

Blaylock, R.L., et al. Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Curr Med Chem. 2009;16(2):157-70.

Camilleri, M. Serotonin in the gastrointestinal tract. Curr Opin Endrocrinol Diabetes Obes. 2009 Feb;16(1):53-9.

Gabriele, S., et al. Blood serotonin levels in autism spectrum disorder: a systematic review and meta-analysis. Eur Neuropsychopharmacol. 2014;24(6):919-29.

Hyman, M.A. Is the Cure for Brain Disorders Outside the Brain? Alternative Therapies in Health and Medicine. Nov-Dec 2007;13(6):10-5.

Verena, L., et al. Elimination diets’ efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry. 2017; 26(9): 1067–1079.


Blaylock, Russell, MD. Excitotoxins: The Taste That Kills. Health Press. New Mexico. 1996.

Davis, William, MD. Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health. Rodale Books. 2014.

Perlmutter, David, MD. Grain Brain: The Surprising Truth about Wheat, Carbs and Sugar — Your Brain’s Silent Killers. Little, Brown and Company. 2013.

Philpott, William, MD. Brain Allergies: The Psycho-Nutrient Connection. Keats Publishing. 1980.

Walsh, William J., PhD. Nutrient Power: Heal Your Biochemistry and Heal Your Brain. Skyhorse Publishing. 2014.