What Is Autism Spectrum Disorder?
Autism spectrum disorder is a developmental disorder characterized by impairments in sensory, language, social-emotional and behavior areas.
It is a “spectrum disorder,” with manifestations ranging from mild to severe.
What Your Doctor May Tell You About Autism
Traditional practitioners believe that autism is a mystery.
They may say that, “We have little knowledge of possible causes, and that treatments should address impairments in the processing of touch, movement, audition and vision, speech, language, and behavior.
Accompanying physical issues such as allergies, breathing problems, gastrointestinal issues, and others are unrelated to the diagnosis.”
Another Way to Think About Autism
Autism spectrum disorder is a multi-system developmental disorder caused by an accumulation of environmental stressors turning on a genetically susceptible predisposition to the condition.
Just like a bridge that collapses when a heavily laden truck crosses it, the body collapses into autism as the multiple triggers add up.
Depending upon the triggers, different systems are affected in each individual, related to his/her bioindividuality.
Autism can be related to:
- Visual processing
- Auditory processing
- Sensory processing
- Retained primitive reflexes
- Food sensitivities and intolerances
- A neurotransmitter imbalance
- Environmental toxins such as lead
- Gut dysbiosis
- Immune dysregulation
The good news is that recovery is possible from autism by rebalancing the body and bringing it back to health.
This requires removing the possible triggers from the external and internal environment, and adding necessary nutrients through food and supplementation.
Autism, ADD/ADHD and SPD Comorbidities
Knowledgeable practitioners have found that roughly 30-50% of children with autism, ADD/ADHD and Sensory Processing Disorder (SPD) also have PANS PANDAS.
These are newer diagnoses that your child’s pediatrician or psychiatrist may not be aware of.
They are disorders that are loosely defined as a sudden onset of acute anxiety and mood variability accompanied by OCD (Obsessive Compulsive Disorder) and/or tics.
PANDAS stands for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. With PANDAS, the onset of symptoms is typically preceded by streptococcal -A infection (“strep throat”). However, in some cases, children may not have presented with a full-blown, acute strep throat infection.
PANDAS is included in the larger umbrella of PANS, Pediatric Acute-onset Neuropsychiatric Syndrome. PANS includes not only PANDAS, but also diagnoses such as Lyme disease, OCD and ODD.
In addition, it is very common for younger siblings of children diagnosed with autism, ADD/ADHD or Sensory Processing Disorder to be diagnosed themselves with PANS and PANDAS.
If this is the case, consider that your older child may have PANS PANDAS as well.
In many cases, these children have both a PANDAS diagnosis as well as that of Lyme disease.
Another way to think of PANS PANDAS, as well as any neurodevelopmental disorder such as autism, ADD/ADHD, Sensory Processing Disorder and even learning disabilities, is that these disorders may fall under the larger umbrella of autoimmune encephalitis (AE).
Autoimmune encephalitis is a disorder in which the immune system attacks the brain, impairing function.
Encephalitis is inflammation and swelling of the brain, often due to infection, which in many of these cases causes an autoimmune attack on the microglia cells of the brain.
A child with this type of damage may typically never have or may lose motor skills and/or the ability to speak, similar to an adult who has had a stroke.
Encephalitis is a common symptom of this type of damage, and it often shows up as an increase in the child’s head-circumference percentile, especially in the first year of life.
The prestigious science journal Nature pointed this out by stating that “brain volume overgrowth was linked to the emergence and severity of autistic social deficits.”
Anti-NDMA Receptor Encephalitis
The N-methyl-D-aspartate receptor (also known as the NMDA receptor), is a glutamate receptor found in nerve cells.
It is activated when the amino acids glutamate and glycine bind to it.
NMDA receptors have been implicated by a number of studies to be strongly involved with excitotoxicity, the process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate.
Excitoxicity can cause encephalopathy and seizures.
Glutamate and its analogs are found in processed foods not only as MSG (monosodium glutatmate), but also in chemical food additives such as:
- Hydrolyzed vegetable protein
- Soy protein isolate
- Yeast extract
- Barley malt
- Natural flavoring
- Artificial flavoring
- Soy sauce
Even natural foods such as tomatoes, bone broth and seaweed may naturally have high levels of glutamate.
Strep also increases glutamate in the brain.
Autism Checklist to Start
Consider lifestyle contribution:
- Is your child getting 10 hours of sleep per night (or more if your child is under 10)?
- An hour of exercise or movement per day?
- Drinking half his body weight in ounces of water?
Make dietary changes:
Is your child craving and eating primarily a refined carbohydrate, high sugar, trans-fatty acids and fast food diet?
Eliminate all processed foods, and eat a whole foods diet.
Gluten- and dairy-containing foods are commonly known to produce an inability to focus when eaten.
- Eat whole foods
- Buy organic foods
- Remove all GMO foods
- Remove all fast and processed foods
- Remove all foods with:
- Artificial colors
- Artificial ingredients
- With an elimination diet, remove potentially inflammatory foods such as:
- Strictly limit:
- Refined salt
- Refined carbohydrates
- Consider implementing a low glutamate diet and/or the Feingold diet
Include plenty of good quality fats, such as:
- Coconut oil
- Olive oil
- Wild salmon
- Organic chicken
- Organic turkey
- Grass-fed ghee
- Pasture-raised eggs
- Grass-fed beef
- Essential fatty acids from:
- Cod liver oil
- Hemp seeds
- Flax seeds
- Evening primrose oil
- Borage oil
- Walnut oil
Remove vegetable oils such as:
Include plenty of high-quality proteins with every meal, such as:
- Pasture-raised eggs and chicken
- Grass-fed beef
- Wild-caught fish
Heal the gut with special diets such as:
- GAPS (Gut And Psychology Syndrome) diet
- Paleo diet
- GF/CF (gluten-free/casein-free) diet
- Body Ecology Diet
- Modified Atkins Diet (replaces the Ketogenic diet)
Learn more about healing diets and foods.
Use digestive aids with your practitioner’s guidance:
- Betaine hydrochloric acid
- Digestive enzymes with DPP-IV for gluten and casein intolerances
- Proteolytic enzymes
Clean up your environment:
Have you identified and removed possible environmental triggers, such as mold, dust, pet dander, and electromagnetic fields (EMFs)?
Have you identified and removed possible toxic exposures in the home from purchased products, such as detergents, soaps, lotions, and other cleaning and personal care products?
- Remove animals (both live and stuffed!)
- Remove carpets
- Use non-toxic cleaners
- Use non-toxic building materials
- Green your home
Ask your pediatrician to run some laboratory tests for:
- Possible food sensitivities and allergies
- Enzyme-Linked Immunosorbent Assay (ELISA) IgG, IgA, IgE and IgM
- Nutritional deficiencies in vitamins and minerals. The NutrEval by Genova Diagnostics Labs covers the following areas:
- Cellular energy
- Mitochondrial metabolism
- Neurotransmitter metabolism
- Vitamin deficiencies
- Toxin exposure
- Detoxification need
- Bacterial and yeast overgrowth
- Gluten and casein sensitivities
- Organic acids: The organic acid test by Great Plains Laboratory for yeast overgrowth and Candida, oxalates, and other microbial infections
Add fermented foods and probiotics daily:
These will keep the gastrointestinal system and microbiome healthy and strong which in turn will keep the immune system strong.
- Eat kefir yogurts
- Eat fermented vegetables
- Eat umeboshi plums (very alkalizing)
- Eat miso soup, if soy is tolerated
Some good probiotics are:
- Gut Pro
- Dr. Ohirra’s Live Cultured Probiotics
- Garden of Life
- Klaire Labs
Use herbs, essential oils and natural supplements with your practitioner’s guidance:
- Cod liver oil
- Vitamin C
- Vitamin D3
- B complex vitamins especially pantothenic acid (B5)
- Rescue Remedy
- GABA, especially PharmaGABA
- N-acetylcysteine (NAC): prevents upper respiratory infections for those prone to chronic infections
- MSM transdermal cream
- Epsom salts bath
Help your child detoxify:
- Ionic foot baths can help detox unwanted pathogens and are easy to do with children
- Infared saunas can detox heavy metals through the skin by sweating. However, this form of detoxification may not be suitable for young children who lack the ability to sweat.
Learn about retained primitive reflexes:
Most, if not all, children with neurodevelopmental disorders including learning disabilities, have retained primitive reflexes.
Find a therapist that is trained in integrating primitive reflexes, which can cause imbalances in the way your child’s brain performs.
See a chiropractic neurologist at a Brain Balance Center:
The Brain Balance program can help balance the right and left brain hemispheres and make neural connections to extinguish primitive reflexes.
See a neurofeedback practitioner:
Neurofeedback is approved as a level-one intervention by the American Academy of Pediatrics for ADD and ADHD, which are learning disabilities.
Even if your child doesn’t have ADD or ADHD, they may still benefit from neurofeedback.
Find a practitioner that can perform a QEEG (quantitative electroencephalograph) brain map first so you can understand how your child’s brain works.
See a sensory-integration occupational therapist (OT):
These OTs address a variety of sensory issues with a child using hands-on equipment. This type of therapy calms down the nervous system to help integrate the senses and retained reflexes.
See a chiropractor:
A chiropractor can perform spinal cord adjustments, which can improve communication in the nervous system.
See a craniosacral practitioner:
Craniosacral therapy can reestablish central nervous system functioning. These practitioners use approaches rich in vestibular, proprioceptive and tactile input and may also do oral motor therapy.
See a behavioral/developmental optometrist:
A developmental optometrist can check for convergence and tracking problems with your child’s vision. He or she can correct these issues with vision therapy, lens and prisms. Doing so can improve hand-eye coordination and school performance.
See an auditory therapist:
Many children with learning disabilities have auditory processing problems that may be causing problems with focus and concentration. An auditory therapist can devise a listening program that is specific to your child’s needs.
Auditory Integration Therapy (Berard) or Sound Stimulation (Tomatis) can retrain the brain, calm down the nervous system, reduce sound sensitivities.
Find a therapist doing Brain Gym:
A Brain Gym practitioner can have your child do exercises for sensorimotor coordination, self-calming and self-management.
See a homeopath or naturopath:
These practitioners can diagnose and treat gastrointestinal disorders naturally so that the child’s immune, sensory, neurological and nervous systems develop without being compromised.
See a well-trained acupuncturist:
Acpuncture can help lower stress and anxiety associated with sensory processing.
See a NAET or BioSET practitioner:
Children with Sensory Processing Disorder typically also have food allergies and/or food sensitivities and intolerances. NAET (Namudripad’s Allergy Elimination Technique) and BioSET are two non-invasive methods of allergy elimination.
Sensory therapies and tools:
- Super brain yoga
- Rock climbing
- Weighted vests, blanket and belts
- HANDLE therapy
- Sensory Learning
- Tool Chest
- Squeeze Machine
- Music therapy
- Sensory gym
- Deep pressure brushing therapy
- Sensory tactile toys
Still Looking for Answers?
- Have your child screened for services from the local public school, even if your child does not attend. The law mandates that you are entitled to free services from birth.
- Ask your doctor to run basic blood, urine, and stool tests for baselines on function. Be sure and include a test for vitamin D, which is not routine.
- Take all processed foods out of your child’s diet. Consider removing all sugars, flours (especially wheat), and dairy products, as well.
- Look into diets and therapies that heal the gut and restore microbial balance and diversity in your child’s gastrointestinal system
- Seek out a local support group for families of children with special needs.
Sources & References
Adams, J.B., et al. Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial. Nutrients. 2018 Mar 17;10(3).
Adams, J.B., et al. Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatr. 2011;11:111.
Adams, J.B., et al. Mercury in first-cut baby hair of children with autism versus typically-developing children. Toxicological & Environmental Chemistry. 2007 Jun;70(12):1046-51.
Adams, J.B., et al. Mercury, Lead, and Zinc in Baby Teeth of Children with Autism Versus Controls. Journal of Toxicology and Environmental Health. 2007 Jun;70(12):1046-51.
Adams, J.B., et al. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutr Metab (Lond). 2011 Jun 8;8(1):34.
Alabdali, A., et al. A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders. Behav Brain Funct. 2014;10:14
Alabdali, A., et al. Association of social and cognitive impairment and biomarkers in autism spectrum disorders. J Neuroinflammation. 2014;11:4
Atladóttir, H.Ó., et al. Autism after infection, febrile episodes, and antibiotic use during pregnancy: an exploratory study. Pediatrics. 2012 Dec;130(6):e1447-54.
Ashraghi, R.S., et al. Early Disruption of the Microbiome Leading to Decreased Antioxidant Capacity and Epigenetic Changes: Implications for the Rise in Autism. Front. Cell. Neurosci., 15 Aug 2018.
Ashwood, P., et al. The immune response in autism: a new frontier for autism research. Journal of Leukocyte Biology. 2006 Jul;80(1):1-15.
Baker, S. Canaries and Miners. Alternative Therapies in Health and Medicine. Nov-Dec 2008;14(6):24-6.
Barrett, B. Substantial lifelong cost of autism spectrum disorder. J Pediatr. 2014;165(5):1068-9
Bateman, C. Autism–mitigating a global epidemic. S Afr Med J. 2013;103(5):276-7
Bitsika, V., et al. Hypothalamus-pituitary-adrenal axis daily fluctuation, anxiety and age interact to predict cortisol concentrations in boys with an autism spectrum disorder. Physiol Behav. 2015;138:200-7
Blaylock, R.L. A possible central mechanism in autism spectrum disorders, part 1. Altern Ther Health Med. 2008 Nov-Dec;14(6):46-53.
Blaylock, R.L. A possible central mechanism in autism spectrum disorders, part 2: immunoexcitotoxicity. Altern Ther Health Med. 2009 Jan-Feb;15(1):60-7.
Blaylock, R.L. A possible central mechanism in autism spectrum disorders, part 3: the role of excitotoxin food additives and the synergistic effects of other environmental toxins. Altern Ther Health Med. 2009 Mar-Apr;15(2):56-60.
Blaylock, R.L., et al. Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Curr Med Chem. 2009;16(2):157-70.
Borre, Y.E., et al. Microbiota and neurodevelopmental windows: implications for brain disorders. Trends Mol Med. 2014 Sep;20(9):509-18.
Bouder, et al. Brief report: Quantifying the impact of autism coverage on private insurance premiums. J Autism Dev Disord. 2009;39(6):953-7
Bradstreet, et al. Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder. Altern Med Rev. 2010;15(1):15-32
Bransfield, R.C., et al. The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders. Medical Hypotheses. 2008;70(5):967-74.
Brown, et al. Observable essential fatty acid deficiency markers and autism spectrum disorder. Breastfeed Rev. 2014;22(2):21-6.
Buescher, et al. Costs of autism spectrum disorders in the United Kingdom and the United States. JAMA Pediatr. 2014;168(8):721-8.
Bull, G., et al. Indolyl-3-acryloylglycine (IAG) is a putative diagnostic urinary marker for autism spectrum disorders. Med Sci Monit. 2003;9(10):CR422-5.
Camilleri, M. Serotonin in the gastrointestinal tract. Curr Opin Endrocrinol Diabetes Obes. 2009 Feb;16(1):53-9.
Connolly, A.M., et al. Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders. The Journal of Pediatrics. 1999 May;134(5):607-13.
Critchfield, et al. The potential role of probiotics in the management of childhood autism spectrum disorders. Gastroenterol Res Pract. 2011;2011:161358.
Cubala-Kucharska M. The review of most frequently occurring medical disorders related to aetiology of autism and the methods of treatment. Acta Neurobiol Exp (Wars). 2010;70(2):141-6.
Dale, R.C., et al. Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity. Brain. 2004 Jan;127(Pt 1):21-33.
Darling, A.L., et al. Association between maternal vitamin D status in pregnancy and neurodevelopmental outcomes in childhood: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Br J Nutr. 2017 Jun;117(12):1682-1692.
Dave, D., et al. The effect of an increase in autism prevalence on the demand for auxiliary healthcare workers : evidence from California. Cambridge, MA: National Bureau of Economic Research; 2012. 37 p.p.
Deisher, T.A., et al. Impact of environmental factors on the prevalence of autistic disorder after 1979. J Public Health and Epidemiology. Sep 2014;6(9):271-286.
de Magistris, et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatr Gastroenterol Nutr. 2010;51(4):418-24
Deth, R., et al. How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. Neurotoxicology. 2008;29(1):190-201
Elamin, N.E., et al. Brain autoantibodies in autism spectrum disorder. Biomark Med. 2014;8(3):345-52
El-Ansary, A., et al. Neuroinflammation in autism spectrum disorders. J Neuroinflammation. 2012;9:265.
El-Ansary, A., et al. Lipid mediators in plasma of autism spectrum disorders. Lipids Health Dis. 2012;11:160.
Egset, K., et al. Magno App: Exploring Visual Processing in Adults with High and Low Reading Competence. Scandinavian Journal of Educational Research. 07 Jan 2020.
Erickson, C.A., et al. Gastrointestinal Factors in Autistic Disorder: A Critical Review. Journal of Autism and Developmental Disorders. 2005 Dec;35(6):713-27.
Faber, S., et al. A cleanroom sleeping environment’s impact on markers of oxidative stress, immune dysregulation, and behavior in children with autism spectrum disorders. BMC Complement Altern Med. 2015;15:71
Frustaci, A., et al. Oxidative stress-related biomarkers in autism: systematic review and meta-analyses. Free Radic Biol Med. 2012;52(10):2128-41
Frye, R.E., et al. Redox metabolism abnormalities in autistic children associated with mitochondrial disease. Transl Psychiatry. 2013;3:e273
Frye, R.E., et al. Metabolic pathology of autism in relation to redox metabolism. Biomark Med. 2014;8(3):321-30
Gabriele, S., et al. Blood serotonin levels in autism spectrum disorder: a systematic review and meta-analysis. Eur Neuropsychopharmacol. 2014;24(6):919-29
Gadow, K.D., et al. Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. J Autism Dev Disord. 2009;39(11):1542-51
Gadow, K.D., et al. Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. Eur J Neurosci. 2010;32(6):1058-65
Gebril, O.H., et al. HFE gene polymorphisms and the risk for autism in Egyptian children and impact on the effect of oxidative stress. Dis Markers. 2011;31(5):289-94
Geier, D.A., et al. The biological basis of autism spectrum disorders: Understanding causation and treatment by clinical geneticists. Acta Neurobiol Exp (Wars). 2010;70(2):209-26
Ghanizadeh, A. Increased glutamate and homocysteine and decreased glutamine levels in autism: a review and strategies for future studies of amino acids in autism. Dis Markers. 2013;35(5):281-6
Goldani, A.A., et al. Biomarkers in autism. Front Psychiatry. 2014;5:100
Goncalves, M.V.M., et al. Pediatric acute-onset neuropsychiatric syndrome (PANS) misdiagnosed as autism spectrum disorder. Immunol Lett. 2018 Nov;203:52-53.
Guyol, G. Who’s crazy here?: Steps for recovery without drugs for: ADD/ADHD, addiction & eating disorders, anxiety & PTSD, depression, bipolar disorder, schizophrenia, autism. 1st U.S. ed. Stonington, CT: Ajoite Pub.; 2010. 123 p.p.
Hacohen, Y., et al. N‐methyl‐d‐aspartate (NMDA) receptor antibodies encephalitis mimicking an autistic regression. Dev Med Child Neurol. 2016 Oct;58(10):1092-4.
Hamad, A.F., et al. Prenatal antibiotics exposure and the risk of autism spectrum disorders: A population-based cohort study. PLoS One. 2019 Aug 29;14(8):e0221921.
Herbert, M.R., et al. Autism and environmental genomics. Neurotoxicology. 2006;27(5):671-84.
Herbert, M.R., et al. Autism and EMF? Plausibility of a pathophysiological link part I. Pathophysiology. 2013 Jul;1-19.
Herbert, M.R., et al. Autism and EMF? Plausibility of a pathophysiological link part II. Pathophysiology. 2013 Jun;20(3):211-34.
Herbert, M.R. Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr Opin Neurol. 2010 Apr;23(2):103-10
Hertz-Picciotto, I., et al. Organophosphate exposures during pregnancy and child neurodevelopment: Recommendations for essential policy reforms. PLoS Med. 2018 Oct 24;15(10):e1002671
Heyer, N.J., et al. Disordered porphyrin metabolism: a potential biological marker for autism risk assessment. Autism Res. 2012;5(2):84-92.
Holmes, A., et al. Reduced Levels of Mercury in First Baby Haircuts of Autistic Children. International Journal of Toxicology. Jul-Aug 2003;22(4):277-85.
Horvath, K., et al. Autistic disorder and gastrointestinal disease. Current Opinion in Pediatrics. 2002 Oct;14(5):583-7.
Horvath, K., et al. Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics. 1999 Nov;135(5):559-63.
Howsmon, D. P., et al. Multivariate techniques enable a biochemical classification of children with autism spectrum disorder versus typically‐developing peers: A comparison and validation study. Bioengineering & Translational Medicine. 2018. doi:10.1002/btm2.10095.
Hyman, M. Autism: Is It All in the Head? Alternative Therapies in Health and Medicine. Nov-Dec 2008;14(6):12-5.
Isaksson, J., et al. Brief Report: Association Between Autism Spectrum Disorder, Gastrointestinal Problems and Perinatal Risk Factors Within Sibling Pairs. J Autism Dev Disord. 2017 Aug;47(8):2621-2627.
Ivanovski, I., et al. Aluminum in brain tissue in autism. J Trace Elem Med Biol. 2019 Jan;51:138-140.
Jafari, M.H., et al. The Relationship Between the Level of Copper, Lead, Mercury and Autism Disorders: A Meta-Analysis. Pediatric Health, Medicine and Therapeutics. 21 Sep 2020(11):369—378.
James, S.J., et al. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J. 2009 Aug;23(8):2374-83.
James, S.J., et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004;80(6):1611-7.
Jyonouchi, H., et al. Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention. Neuropsychobiology. 2005;51(2):77-85.
Jyonouchi, H., et al. Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study. Journal of Neuroinflammation. 2008 Nov 21;5:52.
Kaluzna-Czaplinska, J., et al. Identification of organic acids as potential biomarkers in the urine of autistic children using gas chromatography/mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;966:70-6
Kang, D.W., et al. Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017 Jan 23;5(1):10.
Kang, D.W., et al. Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota. Scientific Reports. 9, 5821 (2019).
Kern, J.K., et al. A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder. Biometals. 2010;23(6):1043-51
Khan, Z., et al. Slow CCL2-dependent translocation of biopersistent particles from muscle to brain. BMC Med. 2013 Apr 4;11:99.
Konstantareas, M.M., et al. Ear infections in autistic and normal children. Journal of Autism and Developmental Disorders. 1987 Dec;17(4):585-94.
Kuwabara, H., et al. Altered metabolites in the plasma of autism spectrum disorder: a capillary electrophoresis time-of-flight mass spectroscopy study. PLoS One. 2013;8(9):e73814.
Lathe, R. Environmental factors and limbic vulnerability in childhood autism; Clinical report. American Journal of Biochemistry and Biotechnology. 4 (2): 183-197, 2008.
Lavelle, T.A., et al. Economic burden of childhood autism spectrum disorders. Pediatrics. 2014;133(3):e520-9.
Li, S.O., et al. Serum copper and zinc levels in individuals with autism spectrum disorders. Neuroreport. 2014;25(15):1216-20.
Li, Y., et al. Association between MTHFR C677T/A1298C and susceptibility to autism spectrum disorders: a meta-analysis. BMC Pediatrics. 2020(20)449.
Liao, T.C., et al. Comorbidity of Atopic Disorders with Autism Spectrum Disorder and Attention Deficit/Hyperactivity Disorder. J Pediatr. 2016 Apr;171:248-55.
Maher, P. Methylglyoxal, advanced glycation end products and autism: is there a connection? Med Hypotheses. 2012;78(4):548-52.
Momeni, N., et al. A novel bloodbased biomarker for detection of autism spectrum disorders. Transl Psychiatry. 2012;2:e91.
Morris, C.R., et al. Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation. Alternative Therapies in Health and Medicine. Jul-Aug 2009;15(4):34-43.
Nankova, B.B., et al. Enteric bacterial metabolites propionic and butyric acid modulate gene expression, including CREB-dependent catecholaminergic neurotransmission, in PC12 cells–possible relevance to autism spectrum disorders. PLoS One. 2014;9(8):e103740
Nemecheck, P., et al. Autism Spectrum Disorder Symptoms Improve with Combination Therapy Directed at Improving Gut Microbiota and Reducing Inflammation. Applied Psychiatry. 2020 Jul; (1)1.
Ngounou Wetie, A.G., et al. A pilot proteomic study of protein markers in autism spectrum disorder. Electrophoresis. 2014;35(14):2046-54.
Nicolson, G.L., et al. Chronic Mycoplasmal Infections in Autism Patients. Proc. Intern. Mind of a Child Conference, Sydney, Australia 2002.
Nicolson, G.L., et al. Evidence for Mycoplasma ssp., Chlamydia pneunomiae, and human herpes virus-6 coinfections in the blood of patients with autistic spectrum disorders. J Neurosci Res. 2007 Apr;85(5):1143-8.
Noto, A., et al. The urinary metabolomics profile of an Italian autistic children population and their unaffected siblings. J Matern Fetal Neonatal Med. 2014;27 Suppl 2:46-52.
Oliveira, G., et al. Mitochondrial dysfunction in autism spectrum disorders: a population-based study. Dev Med Child Neurol. 2005 Mar;47(3):185-9.
Ozonoff, S., et al. Onset patterns in autism: Variation across informants, methods, and timing. Autism Res. 2018 Mar 10.
Palmer, R.F., et al. Proximity to point sources of environmental mercury release as a predictor of autism prevalence. Health and Place. 2009 Mar;15(1):18-24.
Palmieri, L., et al. Mitochondrial dysfunction in autism spectrum disorders: Cause or effect? Biochim Biophys Acta. 2010 June – July;1797(6-7):1130-1137.
Pastural, E., et al. Novel plasma phospholipid biomarkers of autism: mitochondrial dysfunction as a putative causative mechanism. Prostaglandins Leukot Essent Fatty Acids. 2009 Oct;81(4):253-64.
Patrick, R.P., et al. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014;28(6):2398-413.
Patterson, P.H. Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav Brain Res. 2009 Dec 7;204(2):313-21.
Pessah, I.N., et al. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology. 2008 May;29(3):532-45.
Peterson, B.S., et al. Brain lactate as a potential biomarker for comorbid anxiety disorder in autism spectrum disorder-reply. JAMA Psychiatry. 2015;72(2):190-1.
Qiu, C., et al. Association Between Epidural Analgesia During Labor and Risk of Autism Spectrum Disorders in Offspring. JAMA Pediatr. 2020 Oct 12.
Ranjbar, A., et al. Comparison of urinary oxidative biomarkers in Iranian children with autism. Res Dev Disabil. 2014;35(11):2751-5.
Ratajczak, H.V. Theoretical aspects of autism: biomarkers–a review. J Immunotoxicol. 2011;8(1):80-94
Reynolds, A., et al. Iron status in children with autism spectrum disorder. Pediatrics. 2012;130 Suppl 2:S154-9.
Rossignol, D. Diagnosis Autism: Now What? A Simplified Biomedical Approach. The Autism File. 2009(3).
Rutter, M. Changing concepts and findings on autism. J Autism Dev Disord. 2013;43(8):1749-57
Ruggeri, B., et al. Biomarkers in autism spectrum disorder: the old and the new. Psychopharmacology (Berl). 2014;231(6):1201-16
Spilioti, M., et al. Evidence for treatable inborn errors of metabolism in a cohort of 187 Greek patients with autism spectrum disorder (ASD). Front Hum Neurosci. 2013;7:858
Strunecka, A., et al. Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: A possible role of fluoride and aluminum. Surg Neurol Int. 2018 Apr 9;9:74.
Taurines, R., et al. Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia. Eur Child Adolesc Psychiatry. 2010 May;19(5):441-8.
Theoharides, T.C. Is a subtype of autism an allergy of the brain? Clin Ther. 2013; 35(5):584-91
Thomas, R.H., et al. The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders. J Neuroinflammation. 2012;9:153.
Vargas, D.L., et al. Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology. 2005 Jan;57(1):67-81.
Vojdani, A., et al. A Gut Feeling for Immune Dysregulation & Neuroinflammation in Autism. The Autism File. 2009(31).
Vuillermot, S., et al. Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. Mol Autism. 2017 Mar 7;8:9.
Wang, L., et al. Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders. Biomark Med. 2014;8(3):331-44.
Warner, B.B. The contribution of the gut microbiome to neurodevelopment and neuropsychiatric disorders. Pediatr Res. 2019 Jan;85(2):216-224.
Waterhouse, L. Autism Overflows: Increasing Prevalence and Proliferating Theories. Neuropsychology Review. 2008 Dec;18(4):273-86.
Windham, G.C., et al. Autism Spectrum Disorders in Relation to Distribution of Hazardous Air Pollutants in the San Francisco Bay Area. Environmental Health Perspectives. 2006 Sep;114(9):1438-44.
Winter, C., et al. Dopamine and serotonin levels following prenatal viral infection in mouse—implications for psychiatric disorders such as schizophrenia and autism. European Neuropsychopharmacology. 2008 Oct;18(10):712-6.
Woodman, A.C., et al. Change in autism symptoms and maladaptive behaviors in adolescence and adulthood: the role of positive family processes. J Autism Dev Disord. 2015;45(1):111-26
Wu, D.M., et al. Relationship Between Neonatal Vitamin D at Birth and Risk of Autism Spectrum Disorders: the NBSIB Study. J Bone Miner Res. 2018 Mar;33(3):458-466.
Zaigham, M., et al. Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study. BMC Pregnancy and Childbirth. 2020 (20)564.
Bock, Kenneth. Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders. New York, NY. Ballantine Books, 2008.
Campbell-McBride, Natasha. Gut and Psychology Syndrome: Natural Treatment for Autism, Dyspraxia, A.D.D., Dyslexia, A.D.H.D., Depression, Schizophrenia, 2010.
Giustra-Kozek, Jennifer. Healing without hurting: treating ADHD, apraxia, and autism spectrum disorders naturally and effectively without harmful medication. Howard Beach, NY: Changing Lives Press, 2014.
Herbert, Martha, Weintraub Karen. The Autism Revolution: Whole-Body Strategies for Making Life All It Can Be. New York: Ballantine Books; 2012.
Hong, Maria Rickert. Almost Autism: Recovering Children from Sensory Processing Disorder, A Reference for Parents and Practitioners. 2014.
Kaufman, Raun K. Autism breakthrough: the groundbreaking method that has helped families all over the world. First edition. ed. New York: St. Martin’s Press; 2014. x, 353 p.p.
Lambert, Beth, et al. Brain Under Attack: A Resource for Parents and Caregivers of Children with PANS, PANDAS, and Autoimmune Encephalitis. Answers Publications, 2018.
Lemer, Patricia S. Outsmarting Autism: The Ultimate Guide to Management, Healing and Prevention for Individuals with Autism Spectrum Disorders. Tarentum, PA, Word Association Publishers, 2014.
Romaniec, Mary. Victory Over Autism: Lessons on Raising an Autism-Free Child. New York, NY: Skyhorse Publishing, 2015.
Sears, Robert W. The Autism Book: What Every Parent Needs to Know about Early Detection, Treatment, Recovery, and Prevention. 1st ed. New York, NY: Little, Brown, 2010.
Seroussi, Karyn. Unraveling the Mystery of Autism and Pervasive Developmental Disorder: A Mother’s Story of Research and Recovery. New York: Simon & Schuster, 2000.