GABA and glutamate are neurotransmitters and amino acids that can affect the body’s ability to deal with stress and anxiety. GABA is a calming neurotransmitter, while glutamate is excitatory.
Both are needed for optimal function of the brain, but in this day and age, it is easy to have an excess of glutamate due to:
- Infections that cross the blood-brain barrier (PANS/PANDAS)
- Pyroluria, a condition in which vitamin B6 and zinc are overly excreted
- An excess of free glutamates in the diet
- Toxic heavy metals such as:
- Fipronil, glyphosate and other pesticides
- Electromagnetic frequencies (EMFs)
- Low blood sugar
- Brain inflammation stemming from any of the above factors or other factors
An excess of glutamate can contribute to symptoms of:
- Anxiety and other mood disorders
- Sensory Processing Disorder
- Other neurological disorders
Because of this potential for excess glutamate to be harmful, it’s important to understand how to balance GABA and glutamate.
Here’s what we discussed in this webinar:
- The connection between toxins and anxiety
- Problems with too little GABA and too much glutamate
- The basics in case someone doesn’t know anything about GABA
- How a particular insecticide called fipronil disrupts the GABA glutamate balance and where it is found
- Solutions and alternatives
- The toxic effects of fluoride and how might GABA help
- Surprising sources of fluoride
- The effect of phthalates on anxiety, where are they found, and how GABA helps
- The importance of neurotransmitter support and where you can get it
About Trudy Scott CN
Food Mood Expert Trudy Scott, a certified nutritionist, educates anxious individuals about nutritional solutions for anxiety. She is known for her expertise in the use of targeted individual amino acids, which offer hope and immediate relief from anxiety so other underlying root causes and dietary changes can be addressed with ease.
She also educates about the nutritional solutions for the social anxiety condition pyroluria and the harmful effects of benzodiazepines.
Trudy is the author of The Antianxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood and End Cravings.She is also the host of The Anxiety Summit, an online educational platform for both consumers and health professionals, and dubbed “a bouquet of hope.”
Trudy also educates health professionals via the Anxiety Nutrition Institute, sharing research and practical how-to steps. Learn more at www.anxietynutritioninstitute.
This webinar is not a substitute for medical advice, treatment, diagnosis, or consultation with a medical professional. It is intended for general informational purposes only and should not be relied on to make determinations related to treatment of a medical condition. Epidemic Answers has not verified and does not guaranty the accuracy of the information provided in this webinar.
Sources & References
Blaylock, R.L., et al. Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system. Surg Neurol Int. 2012;3:19.
Breier, A.B., et al. The GABAA/benzodiazepine receptor: implications for the molecular basis of anxiety. J Psychiatric Res. 1990;24 Suppl 2:91-104.
Breitenkamp, A.F., et al. Voltage-gated Calcium Channels and Autism Spectrum Disorders. Curr Mol Pharmacol. 2015;8(2):123-32.
Brown, M.S., et al. Increased glutamate concentration in the auditory cortex of persons with autism and first-degreer elatives: A(1)H-MR study. Autism Res. 2013;6(1):1–10.
Choudhury, P.R., et al. Glutamate mediated signaling in the pathophysiology of autism spectrum disorders. Pharmacol Biochem Behav 100(2012)841–849
Cocito, L., et al. GABA and phosphatidylserine in human photosensitivity: a pilot study. Epilepsy Res. 1994 Jan;17(1):49-53.
Coghlan, S., et al. GABA System Dysfunction in Autism and Related Disorders: From Synapse to Symptoms. Neurosci Biobehav Rev. 2012;36(9):2044–2055.
DeHavenon, A., et al. The Secret “Spice”: An Undetectable Toxic Cause of Seizure. Neurohospitalist. 2011 Oct; 1(4): 182–186.
Ding, H., et al. Molecular Pathogenesis of Anti-NMDAR Encephalitis. Biomed Res Int. 2015;2015:643409.
D’Souza, C.E., et al. GAD65 antibody-associated autoimmune epilepsy with unique independent bitemporal-onset ictal asystole. Epileptic Disord. 2018 Jun 1;20(3):204-208.
Eimerl, S., et al. Acute glutamate toxicity and its potentiation by serum albumin are determined by the Ca2+ concentration. Neurosci Lett. 130 (1991) 125–127
Fernell, E. Further studies of GABA and Glutamate imbalances in autism are important challenges for future research. Acta Paediatr. 2019 Feb;108(2):200-201.
Ford, T.C., et al. Psychosocial deficits across autism and schizotypal spectra are interactively modulated by excitatory and inhibitory neurotransmission. Autism. 2019 Jul 24:1362361319866030.
Hacohen, Y., et al. N‐methyl‐d‐aspartate (NMDA) receptor antibodies encephalitis mimicking an autistic regression. Dev Med Child Neurol. 2016 Oct;58(10):1092-4.
Hassel, B., et al. Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc. J Neurosci Res. 2014 Dec;92(12):1792-800.
Herbert, M.R, et al. Autism and EMF? Plausibility of a pathophysiological link–Part I. Pathophysiology 20.3 (2013): 191-209.
Herbert, M.R., et al. Autism and EMF? Plausibility of a pathophysiological link Part II. Pathophysiology 20.3 (2013): 211-234.
Huang, Y., et al. Pyridoxine Supplementation Improves the Activity of Recombinant Glutamate Decarboxylase and the Enzymatic Production of Gama-Aminobutyric Acid. PLoS One. 2016 Jul 20;11(7):e0157466.
Humphries, P., et al. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. 2008 Apr;62(4):451-62.
Hyland, C. Prenatal phthalate exposure and behavior in the CHAMACOS cohort. Environ Health Perspect. 2019 Oct;127(10):107010.
Kash, S.F., et al. Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A. 1997;94(25):14060–14065.
Khalifa, D., et al. Serum glutamate was elevated in children aged 3-10 years with autism spectrum disorders when they were compared with controls. Acta Paediatr. 2019 Feb;108(2):295-299.
Li, X., et al. Effect of Fluoride Exposure on Anxiety- And Depression-Like Behavior in Mouse. Chemosphere. 2019 Jan;215:454-460.
Luo, P., et al. The role of glutamate receptors in traumatic brain injury: implications for postsynaptic density in pathophysiology. Brain Res Bull. 2011 Jul 15;85(6):313-20.
Lydiard, R.B. The role of GABA in anxiety disorders. J Clin Psychiatry. 2003;64 Suppl 3:21-7.
Manev, H., et al. Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death. Mol Pharmacol. 1989 Jul;36(1):106-12.
Prenatal exposure to fipronil disturbs maternal aggressive behavior in rats. Neurotoxicol Teratol. Nov-Dec 2015;52(Pt A):11-6., J.Z., et al.
The GABA system in anxiety and depression and its therapeutic potential. Neuropharmacology. 2012 Jan;62(1):42-53.
Naaijen, J., et al. Fronto-Striatal Glutamate in Autism Spectrum Disorder and Obsessive Compulsive Disorder. Neuropsychopharmacology. 2017 Nov;42(12):2456-2465.
Napolini, V., et al. The mitochondrial aspartate/glutamate carrier AGC1 and calcium homeostasis: Physiological links and abnormalities in autism. Mol Neurobiol. 44 (2011) 83–92.
Nuss, P. Anxiety disorders and GABA neurotransmission: a disturbance of modulation. Neuropsychiatr Dis Treat. 2015; 11: 165–175.
Ou, D., et al. Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with Type I diabetes mellitus. Diabetologia. 2000 Jun;43(6):750-62.
Pall, M.L., The Autism Epidemic Is Caused by EMFs, Acting via Calcium Channels and Chemicals Acting via NMDA-Rs: Downstream Effects Cause Autism (conference presentation). 2015.
Pall, M.L., Electromagnetic fields act via activation of voltage‐gated calcium channels to produce beneficial or adverse effects. Journal of Cellular and Molecular Medicine 17.8 (2013): 958-965.
Palmieri, L., et al. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC. Mol Psychiatry. 2010 Jan;15(1):38-52.
Qi, J., et al. Enhanced susceptibility to stress and seizures in GAD65 deficient mice. PLoS One. 2018 Jan 29;13(1):e0191794.
Rojas, D.C. The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment. J Neural Transm (Vienna). 2014;121(8):891–905.
Rout, U.K., et al. Presence of GAD65 autoantibodies in the serum of children with autism or ADHD. Eur Child Adolesc Psychiatry. 2012 Mar;21(3):141-7.
Rowley, N.M., et al. Glutamate and GABA synthesis, release, transport and metabolism as targets for seizure control. Neurochem Int. 2012 Sep;61(4):546-58.
Sai, Y., et al. Clinical diagnosis and treatment of pediatric anti-N-methyl-D-aspartate receptor encephalitis: A single center retrospective study. Exp Ther Med. 2018 Aug;16(2):1442-1448.
Savage, K., et al. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Phytother Res. 2018 Jan;32(1):3-18.
Schauwecker, P.A. The effects of glycemic control on seizures and seizure-induced excitotoxic cell death. BMC Neurosci. 2012 Aug 6;13:94.
Silvestrin, R.B., et al. Animal model of autism induced by prenatal exposure to valproate: altered glutamate metabolism in the hippocampus. BrainRes. 1495 (2013) 52–60.
Tang, J., et al. Exposure to 900 MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats. Brain Res. 2015 Mar 19;1601:92-101.
Terpstra, M., et al. Changes in human brain glutamate concentration during hypoglycemia: insights into cerebral adaptations in hypoglycemia-associated autonomic failure in type 1 diabetes. J Cereb Blood Flow Metab. 2014;34(5):876–882.
Tzang, R.F., et al. Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related Therapy. Front Psychiatry. 2019 Jun 21;10:440.
Walls, A.B., et al. GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity. J Neurochem. 2010 Dec;115(6):1398-408.
Wang, Hsiuying. Anti-NMDA Receptor Encephalitis. Int J Mol Sci. 2017 Jan 18;18(1). pii: E193.
Watkins, J.C., et al. The glutamate story. Br J Pharmacol. 2006 Jan; 147(Suppl 1): S100–S108.
Yang, H., et al. Analysis of the Protective Effects of γ-Aminobutyric Acid During Fluoride-Induced Hypothyroidism in Male Kunming Mice. Pharm Biol. 2019 Dec;57(1):29-37.
Yang, Y., et al. Role of metabotropic glutamate receptor 7 in autism spectrum disorders: A pilot study. Life Sci. 92 (2013) 149–153.
Zhang, Z., et al. Blood Glutamate Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. PLoS One. 2016 Jul 8;11(7):e0158688.
Blaylock MD, Russell. Excitoxins: The Taste That Kills. Health Press, 1996.
Lambert, Beth, et al. Brain Under Attack: A Resource for Parents and Caregivers of Children with PANS, PANDAS and Autoimmune Encephalitis. Answers Publications, 2018.
Ross, Julia. The Mood Cure: The 4-Step Program to Take Charge of Your Emotions–Today. Penguin Life, 2003.
Scott, Trudy. The Antianxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood and End Cravings. New Harbinger Publications, 2011.