The Importance of the Microbiome

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We interviewed Raphael Kellman MD about the importance of the microbiome, which is the key to overall mental and physical health. You can watch the replay below.


The microbiome is a miniature ecosystem in the gastrointestinal tract, one populated by trillions of microscopic, non-human organisms. These tiny dwellers digest our food, control our appetite, and regulate our metabolism. These bacteria also orchestrate our immune system, influence our mood, and help determine the expression of our genes.

This inner ecology plays a key role in our health because it can affect multiple systems simultaneously. Healing the microbiome can make many positive changes in your child, such as:

Listen in to find out what can throw the microbiome out of balance and how to bring it back to balance.

Please note that you will be asked to enter your email address at the 30-minute mark to finish viewing the video.

About Raphael Kellman MD

Raphael Kellman MDRaphael Kellman MD is a functional medicine internist and author of The Microbiome Diet: The Scientifically Proven Way to Restore Your Gut Health and Achieve Permanent Weight Loss.

A graduate of Albert Einstein School of Medicine, he has, over the past two decades, treated more than 40,000 patients, developing a global reputation for investigating the root causes of disease and pioneering the use of functional and microbiome medicine.

Dr. Kellman draws on the latest research to address patients’ biochemistry, metabolism, hormones, genetics, environment, emotions, and life circumstances to help them achieve optimal health.

In addition to providing patient care and managing a thriving medical practice, Dr. Kellman publishes and lectures all over the world, advocating for whole-patient care and discussing his cutting-edge approach to curing illness through healing the microbiome.

Dr. Kellman lives with his wife and two young daughters—his greatest inspiration for revolutionizing healthcare—in New York City. You can find out more about him and his practice at www.kellmancenter.com

Disclaimer

This webinar is not a substitute for medical advice, treatment, diagnosis, or consultation with a medical professional. It is intended for general informational purposes only and should not be relied on to make determinations related to treatment of a medical condition. Epidemic Answers has not verified and does not guaranty the accuracy of the information provided in this webinar.

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Sources & References

Aguilera, M., et al. Antibiotic-induced dysbiosis alters host-bacterial interactions and leads to colonic sensory and motor changes in mice. Gut Microbes. 2015;6(1):10-23.

Atladóttir, H.Ó., et al. Autism after infection, febrile episodes, and antibiotic use during pregnancy: an exploratory study. Pediatrics. 2012 Dec;130(6):e1447-54.

Bora, S.A., et al. Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics. J Nutr Biochem. 2018 Jun;56:65-73.

Borchers, A.T., et al. Probiotics and immunity. Journal of Gastroenterology. 44 (2009): 26-46.

Ganal-Vonarburg, S.C., et al. Microbial-host molecular exchange and its functional consequences in early mammalian life. Science. 2020 May 8;368(6491):604-607.

Hamad, A.F., et al. Prenatal antibiotics exposure and the risk of autism spectrum disorders: A population-based cohort study. PLoS One. 2019 Aug 29;14(8):e0221921.

Hanaway, P. Balance of Flora, GALT, and Mucosal Integrity. Alternative Therapies in Health and Medicine. Sep-Oct 2006;12(5):52-60; quiz 61-2.

Hrncir,T., et al. Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice. BMC Immunology. 9 (2008): 65.

Hyman, M.A. Is the Cure for Brain Disorders Outside the Brain? Alternative Therapies in Health and Medicine. Nov-Dec 2007;13(6):10-5.

Kang, D.W., et al. Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome.2017 Jan 23;5(1):10.

Kitano, H., et al. Robustness trade-offs and host-microbial symbiosis in the immune system. Molecular Systems Biology. 2 (2006).

Korpela, K., et al. Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study. Cell, 2020.

Liu, Z., et al. Tight junctions, leaky intestines, and pediatric diseases. Acta Paediatricia. 94 (2005): 386-393.

Mine, Y., et al. Surfactants Enhance the Tight-Junction Permeability of Food Allergens in Human Intestinal Epithelial Caco-2 Cells. International Archives of Allergy and Immunology. 2003 Feb;130(2):135-42.

Montalto, M., et al. Fecal Calprotectin Concentrations in Patients with Small Intestinal Bacterial Overgrowth. Digestive Diseases. 2008;26(2):183-6.

Moser, L.A. Astrovirus Increases Epithelial Barrier Permeability Independently of Viral Replication. Journal of Virology. 2007 Nov;81(21):11937-45.

Nankova, B.B. Nicotinic Induction of Preproenkephalin and Tyrosine Hydroxylase Gene Expression in Butyrate-Differentiated Rat PC12 Cells: A Model for Adaptation to Gut-Derived Environmental Signals. Pediatric Research. 2003 Jan;53(1):113-8.

O’Hara, A.M., et al. The gut flora as a forgotten organ. European Molecular Biology Organization Report 7, no 7 (July 2006): 688-693.

Rautava, S., et al. The Development of Gut Immune Responses and Gut Microbiota: Effects of Probiotics in Prevention and Treatment of Allergic Disease. Current Issues in Intestinal Microbiology. 2002 Mar;3(1):15-22.

Savino, F., et al. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics. 2007 Jan;119(1):e124-30.

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Tobacman, J.K. Review of Harmful Gastrointestinal Effects of Carrageenan in Animal Experiments. Environmental Health Perspectives. 2001 Oct;109(10):983-94.

Vael, C., et al. Early intestinal Bacteroides fragilis colonization and development of asthma. BMC Pulmonary Medicine. 2008 Sep 26;8:19.

Warner, B.B. The contribution of the gut microbiome to neurodevelopment and neuropsychiatric disorders. Pediatr Res. 2019 Jan;85(2):216-224.

Wexler, H. Bacteroides: the Good, the Bad, and the Nitty-Gritty. Clinical Microbiology Reviews 20, no. 4 (October 2007): 593-621.

White, E., et al. The Effect of Nutritional Therapy for Yeast Infection (Candidiasis) in Cases of Chronic Fatigue Syndrome. Journal of Orthomolecular Medicine. 2005;20(3).

Resources

Galland, Leo. The Effect of Intestinal Microbes on Systemic Immunity. Excerpted from Power Healing. Random House, 1998.

Kellman, Raphael. The Microbiome Diet: The Scientifically Proven Way to Restore Your Gut Health and Achieve Permanent Weight Loss. Da Capo Lifelong Books, 2015.

Sachs, Jessica Snyder. Good Germs, Bad Germs: Health and Survival in a Bacterial World. Hill and Wang, 2007.

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