The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Nontoxic Bio-Individualized Therapies

By Nasha Winters ND FABNO LAc and Jess Higgins Kelley MNT
This book is the standard for using diet, therapies and bioindividual strategies in an integrated way to heal from cancer. The metabolic approach of which the authors write is based on controlling blood-sugar levels - because sugar feeds cancer - and also includes what the authors call the Terrain Ten elements to help the body heal. This truly integrative approach takes into account epigenetics, toxicity, immune dysregulation, the microbiome, inflammation, hormonal imbalances, stress and more. We highly recommend this book as a must-have for those wishing to understand how to heal from cancer.

The Metabolic Approach to Cancer was written with the goal of empowering cancer patients. One of the authors, Nasha Winters, is a decades-long survivor of end-stage ovarian cancer, with which she was diagnosed at the age of 19. Facing the possible end of her life as a newly minted adult, Dr. Winters quickly learned about integrative approaches to cancer including a traditional whole-foods diet and complementary medicine. These strategies are discussed in the book, and she is living proof of their potential efficacy.

What Causes Cancer?

A 2008 study, Cancer Is a Preventable Disease That Requires Major Lifestyle Changes, demonstrated that 90-95% of cancers can be attributed to unhealthy diet and lifestyle factors. In other words, your “DNA is not your destiny.” This statistic can be a motivating factor to patients that want to empower themselves to make these changes, and this is the goal of the book.

The writers state that “The root cause of cancer is actually damaged mitochondria.” While genetics can control the rate at which mitochondria can be damaged, it’s empowering to know that there are workarounds to DNA mutations such as the MTHFR mutation. (In this particular case, the workaround is eating leafy green vegetables and taking methylated B vitamins and other methylated supplements.) In addition, it’s empowering to know that mitigating and correcting lifestyle factors such as circadian rhythm, toxin exposure, sleep quality, movement, stress, microbiome imbalances and more can dramatically improve the body’s healing response.

Why the Metabolic Approach Is Key

The central thesis of the book is “Cancer is not a genetic disease but instead a metabolic disorder that occurs in response to how we are feeding and treating our bodies and therefore our genomes.” When cancer is looked at through this lens, it quickly becomes apparent that dietary changes are necessary. Because sugar feeds cancer (the Warburg effect), it follows that eliminating sugar and controlling blood glucose are paramount to halting cancer.

Fat cannot be used by cancer cells, so the ketogenic diet is a powerful diet for cancer patients to implement. By itself, it is not the cure for cancer, but it can help with stopping angiogenesis and controlling cachexia. To this day, we are still stunned by the fact that cancer-treatment centers often give their patients sugary treats. Winters and Kelley write that “low-glycemic, ketogenic diets and intermittent fasting should be an integral part of an effective anticancer diet program.”

What’s Included in the Book

It’s empowering to know that “Cancer treatment does not have to be ‘either-or’”. The metabolic approach can be used in conjunction with conventional treatments of surgery, chemotherapy and radiation. The ketogenic diet is not the only tool that can be used (and if you do choose to follow this diet, please work with a knowledgeable healthcare practitioner, such as one from the Metabolic Terrain Institute of Health, founded by Dr. Winters).

In addition to addressing some of the particulars about the ketogenic diet, the book includes a quiz to assess your Terrain Ten™ risk factors such as:

Other information included in the book includes:

  • Helpful lab tests such as HbA1C, fasting glucose, IGF-1, fasting insulin, fibrinogen, vascular endothelial growth factor (VEGF), serum copper, ceruloplasmin, ferritin and ketones
  • An overview of common carcinogens and their exposure sources
  • A guide to foods that can help with detoxification
  • Therapies such as saunas, hyperthermia, mistletoe, forest bathing, hydrotherapy, grounding and Hyperbaric Oxygen Therapy (HBOT)
  • Common nutrient deficiencies such as vitamins A, C and D, B vitamins, selenium, magnesium and zinc
  • Common medications such as acetaminophen, antibiotics and acid-reflux remedies that can be contributing to immune dysregulation
  • Immune-boosting foods such as medicinal mushrooms
  • Debunking of common anti-cancer diets such as the Budwig diet, the acid-alkaline diet and the vegan diet
  • Helpful antioxidant foods, supplements and spices
  • Foods and culinary herbs that inhibit angiogenesis and metastasis
  • Tips for cleaning out and restocking your kitchen

In Conclusion

If there is only one book that you buy to learn more about healing from cancer, we believe that The Metabolic Approach to Cancer should be your first choice. This book is an excellent reference for those empowered people who are willing to make the book’s recommended dietary and integrative changes. However, you should only make these changes with the help of your doctor and your other healthcare practitioners; it does not replace your relationship with them.

About Nasha Winters ND FABNO LAc

Dr. Nasha Winters is a global healthcare authority in integrative cancer care and research consulting with physicians around the world. She is the best-selling author of The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Nontoxic Bio-Individualized Therapies. She has educated hundreds of professionals in the clinical use of mistletoe and has created robust educational programs for both healthcare institutions and the public on incorporating vetted integrative therapies in cancer care to enhance outcomes.

Dr. Winters is currently focused on opening a comprehensive metabolic oncology hospital and research institute in the U.S. where the best that standard of care has to offer and the most advanced integrative therapies will be offered. This facility will be in a residential setting on a gorgeous campus against a backdrop of regenerative farming, EMF mitigation and retreat. You can find out more about her at her websites www.drnasha.com and https://mtih.org

Nasha Winters ND FBANO

About Jess Higgins Kelley MNT ONC

Jess is a Master Nutrition Therapist, Oncology Nutrition Consultant, teacher, writer, and nutrition education program developer. An Oncology Nutrition Consultant for over a decade, Jess has extensive experience working with cancer and chronic illness clients from around the globe.

She is also the co-author of two books, The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Nontoxic Bio-Individualized Therapies (Chelsea Green Publishing, May 2017) and Bioregulatory Medicine: An Innovative Holistic Approach to Self-Healing (Chelsea Green Publishing, November 2018).

Jess is the Founder and Director at the Oncology Nutrition Institute which provides online certification programs for professionals and education for the public in therapeutic metabolic nutrition. An avid researcher and student, Jess has completed certifications in Environmental Medicine through the University of Arizona Medical School, Nutrigenomics through Nutrition Genome, Endocrinology and Blood Chemistry Analysis through Apex Energetics, Scientific Phytotherapy through alchemlife, and Methylation and Clinical Nutrigenomics through Bastyr University. Jess was an instructor at the Nutrition Therapy Institute in Denver, Colorado from 2011-2017 and believes strongly in empowerment through education.

She holds a B.A. in Journalism from Western Colorado University and has written health and nutrition articles for a variety of local and national publications including Breast Cancer Wellness Magazine and is the former managing editor of Edible Southwest Magazine. Formerly a sea captain and lead Hurricane Island Outward Bound Instructor, Jess strongly believes in physical activity and spending as much time as possible outdoors connecting with nature. When not writing, teaching, or consulting with clients, Jess is trail running, skiing, surfing, sailing, doing yoga, gardening or spending time with her family. You can find out more about her work at her website https://www.remissionnutrition.com/

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Sources & References

Accurso, A., et al. Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal. Nutr Metab (Lond). 2008 Apr 8:5:9.

Acuña-Catalán, D., et al. Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice. Cell Rep Med. 2024 Jun 18;5(6):101593.

Adebayo, O., et al. The changing face of diabetes in America. Emerg Med Clin North Am. 2014;32(2):319-27.

Aggarwal, B.B., et al. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 2006 May 14;71(10):1397-421.

Ai, Y., et al. The relationship between diabetes mellitus and attention deficit hyperactivity disorder: A systematic review and meta-analysis. Front Pediatr. 2022 Sep 29:10:936813.

Al-Khatib, Y., et al. Depression and Metabolic Syndrome: A Narrative Review. Cureus. 2022 Feb 12;14(2):e22153.

Al-Onaizi, M., et al. Glucose intolerance induces anxiety-like behaviors independent of obesity and insulin resistance in a novel model of nutritional metabolic stress. Nutr Neurosci. 2024 Oct;27(10):1143-1161.

Allen, B.G., et al. Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism. Redox Biol. 2014:2:963-70.

Anand, P., et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008 Sep;25(9):2097-116.

Aucoin, M., et al. Generalized anxiety disorder and hypoglycemia symptoms improved with diet modificationCase Rep Psychiatry. 2016;2016.

Bădescu, S.V., et al. The association between Diabetes mellitus and Depression. J Med Life. 2016 Apr-Jun; 9(2): 120–125.

Bahr, L.S., et al. Ketogenic diet and fasting diet as Nutritional Approaches in Multiple Sclerosis (NAMS): protocol of a randomized controlled study. Trials. 2020 Jan 2;21(1):3.

Banerjee, S., et al. Ayurveda in changing scenario of diabetes management for developing safe and effective treatment choices for the future. J Complement Integr Med. 2015.

Basic, M., et al. Obesity: genome and environment interactions. Arh Hig Rada Toksikol. 2012;63(3):395-405.

Bernstein, R.K. Blood glucose self-monitoring by diabetic patients: refinements of procedural technique. Diabetes Care. 1979 Mar-Apr;2(2):233-6.

Bernstein, R.K. Virtually continuous euglycemia for 5 yr in a labile juvenile-onset diabetic patient under noninvasive closed-loop control. Diabetes Care. 1980 Jan-Feb;3(1):140-3.

Bipartisan Policy Center. Lots to lose how America’s health and obesity crisis threatens our economic future. Washington, D.C.: Bipartisan Policy Center,; 2012.

Blázquez, E., et al. Significance of Brain Glucose Hypometabolism, Altered Insulin Signal Transduction, and Insulin Resistance in Several Neurological Diseases. Front Endocrinol (Lausanne). 2022 May 9:13:873301.

Boison, D. New insights into the mechanisms of the ketogenic diet. Curr Opin Neurol. 2017 Apr;30(2):187-192.

Bolin K, Cawley JH. The economics of obesity. 1st ed. Amsterdam; Boston: Elsevier JAI; 2007. xxiii, 364 p.p.

Bostock, E.C.S., et al. The Current Status of the Ketogenic Diet in Psychiatry. Front Psychiatry. 2017 Mar 20:8:43.

Bradford, B.L., et al. Mitochondrial Dysfunction and Type 2 Diabetes. Science. 2005 Jan 21;307(5708):384-7.

Bradley, R., et al. Algorithm for complementary and alternative medicine practice and research in type 2 diabetes. J Altern Complement Med. 2007 Jan-Feb;13(1):159-75.

Brenton, J.N., et al. Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits. J Neurol Neurosurg Psychiatry. 2022 Jun;93(6):637-644.

Brenton, J.N., et al. Pilot study of a ketogenic diet in relapsing-remitting MS. Neurol Neuroimmunol Neuroinflamm. 2019 Apr 12;6(4):e565.

Brietzke, E., et al. Ketogenic diet as a metabolic therapy for mood disorders: Evidence and developments. Neurosci Biobehav Rev. 2018 Nov:94:11-16.

Calabrese, L., et al. Complete remission of depression and anxiety using a ketogenic diet: case series. Front Nutr. 2024 May 14:11:1396685.

Campbell, I.H., et al. Ketosis and bipolar disorder: controlled analytic study of online reports. BJPsych Open. 2019 Jul 4;5(4):e58.

Campbell, I.H., et al. The metabolic overdrive hypothesis: hyperglycolysis and glutaminolysis in bipolar mania. Mol Psychiatry. 2024 May;29(5):1521-1527.

Carlson, J.A., et al. Dietary-related and physical activity-related predictors of obesity in children: a 2-year prospective study. Child Obes. 2012;8(2):110-5.

Centers for Disease Control and Prevention. All About Your A1C.

Centers for Disease Control and Prevention. Diabetes Tests.

Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020: Estimates of Diabetes and Its Burden in the United States.

Cheng, N., et al. Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches. Front Mol Neurosci. 2017 Feb 21:10:34.

Chmiel, I. Ketogenic diet in therapy of bipolar affective disorder - case report and literature review. Psychiatr Pol. 2022 Dec 31;56(6):1345-1363.

Choquet, H., et al. Genomic insights into early-onset obesity. Genome Med. 2010;2(6):36.

Classen, J.B. Review of evidence that epidemics of type 1 diabetes and type 2 diabetes/metabolic syndrome are polar opposite responses to iatrogenic inflammation. Curr Diabetes Rev. 2012;8(6):413-8.

Coller, H.A. Is cancer a metabolic disease? Am J Pathol. 2014 Jan;184(1):4-17.

Cortese, S., et al. The Association between ADHD and Obesity: Intriguing, Progressively More Investigated, but Still Puzzling. Brain Sci. 2019 Sep 27;9(10):256.

Cortese, S., et al. Attention-deficit/hyperactivity disorder, iron deficiency, and obesity: is there a link? Postgrad Med. 2014;126(4):155-70.

Cui, J., et al. Butyrate-Producing Bacteria and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES). Diabetes. 2022 Nov 1;71(11):2438-2446.

Danan, K., et al. The Ketogenic Diet for Refractory Mental Illness: A Retrospective Analysis of 31 Inpatients. Front Psychiatry. 2022 Jul 6:13:951376.

deCampo, D.M., et al. Ketogenic dietary therapies for epilepsy and beyond. Curr Opin Clin Nutr Metab Care. 2019 Jul;22(4):264-268.

de la Rubia Orti, J.E., et al. Can Ketogenic Diet Improve Alzheimer’s Disease? Association With Anxiety, Depression, and Glutamate System. Front Nutr. 2021 Oct 27:8:744398.

de la Rubia Orti, J.E., et al. Exploring the impact of ketogenic diet on multiple sclerosis: obesity, anxiety, depression, and the glutamate system. Front Nutr. 2023 Aug 25:10:1227431.

Desai, J.R., et al. Diabetes and asthma case identification, validation, and representativeness when using electronic health data to construct registries for comparative effectiveness and epidemiologic research. Med Care. 2012;50 Suppl:S30-5.

Dietch, D.M., et al. Efficacy of low carbohydrate and ketogenic diets in treating mood and anxiety disorders: systematic review and implications for clinical practice. BJPsych Open. 2023 Apr 17;9(3):e70.

Douglas, B.L., et al. Washington Business Group on Health. Obesity an overview of an American epidemic. Washington, D.C.: Washington Business Group on Health,; 2002.

Duan, W., et al. Hyperglycemia, a neglected factor during cancer progression. Biomed Res Int. 2014:2014:461917.

Dyńka, D., et al. The Role of Ketogenic Diet in the Treatment of Neurological Diseases. Nutrients. 2022 Nov 24;14(23):5003.

Evangeliou, A., et al. Application of a ketogenic diet in children with autistic behavior: pilot study. J Child Neurol. 2003 Feb;18(2):113-8.

Feinman, R.K., et al. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13.

Foster-Powell, K., et al. International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr. 2002 Jul;76(1):5-56.

Freeman, C.R., et al. Impact of sugar on the body, brain, and behavior. Front Biosci (Landmark Ed). 2018 Jun 1;23(12):2255-2266.

Garcia-Argibay, M., et al. The association between type 2 diabetes and attention- deficit/hyperactivity disorder: A systematic review, meta-analysis, and population-based sibling study. Neurosci Biobehav Rev. 2023 Apr:147:105076.

Giovannucci, E., et al. Diabetes and cancer: a consensus report. Diabetes Care. 2010 Jul;33(7):1674-85.

Gough, S., et al. Neuroprotection by the Ketogenic Diet: Evidence and Controversies. Front Nutr. 2021 Nov 23:8:782657.

Grammes, J., et al. Fear of hypoglycemia in patients with type 2 diabetes: The role of interoceptive accuracy and prior episodes of hypoglycemia. J Psychosom Res. 2018;105:58-63.

Grochowska, K., et al. The Effect of the Ketogenic Diet on the Therapy of Neurodegenerative Diseases and Its Impact on Improving Cognitive Functions. Dement Geriatr Cogn Dis Extra. 2022 May 30;12(2):100-106.

Guo, D., et al. Association of maternal diabetes with attention deficit/hyperactivity disorder (ADHD) in offspring: A meta-analysis and review. Diabetes Res Clin Pract. 2020 Jul:165:108269.

Han, H., et al. Gut Microbiota and Type 1 Diabetes. Int J Mol Sci. 2018 Mar 27;19(4):995.

Hao, J., et al. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med. 2009 Apr;13(4):701-11.

He, C., et al. Targeting gut microbiota as a possible therapy for diabetes. Nutr Res. 2015.

Hinzmann, R., et al. What do we need beyond hemoglobin A1c to get the complete picture of glycemia in people with diabetes? Int J Med Sci. 2012;9(8):665-81.

Hou, X., et al. A study of brain glucose metabolism in obsessive-compulsive disorder patients. Ann Palliat Med. 2022 Nov;11(11):3503-3512.

Irish, A.K., et al. Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot study. Degener Neurol Neuromuscul Dis. 2017 Jan 4;7:1-18.

Jiang, Z., et al. Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases. Aging Dis. 2022 Jul 11;13(4):1146-1165.

Johnson, R.J., et al. Attention-deficit/hyperactivity disorder: is it time to reappraise the role of sugar consumption? Postgrad Med. 2011 Sep;123(5):39-49.

Kamba, A., et al. Association between higher serum cortisol levels and decreased insulin secretion in a general populationPLOS ONE. 2016;11(11):e0166077.

Kapoor, D., et al. Emerging Role of the Ketogenic Dietary Therapies beyond Epilepsy in Child Neurology. Ann Indian Acad Neurol. 2021 Jul-Aug;24(4):470-480.

Karkafi, R.E., et al. Ketogenic Diet and Inflammation: Implications for Mood and Anxiety Disorders. Adv Exp Med Biol. 2023:1411:537-554.

Kobayashi, Y., et al. Strength training is more effective than aerobic exercise for improving glycaemic control and body composition in people with normal-weight type 2 diabetes: a randomised controlled trial. Diabetologia. 2023 Oct;66(10):1897-1907.

Kogut, S.J., et al. Evaluation of a program to improve diabetes care through intensified care management activities and diabetes medication copayment reduction. J Manag Care Pharm. 2012;18(4):297-310.

Kong., A.P, et al. Diabetes and its comorbidities–where East meets West. Nat Rev Endocrinol. 2013;9(9):537-47.

Kraft, B.D., et al. Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature. Nutr Metab (Lond). 2009 Feb 26:6:10.

Krikorian, R., et al. Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging. 2012 Feb;33(2):425.e19-27.

Labbé, D.P., et al. Role of diet in prostate cancer: the epigenetic link. Oncogene. 2015 Sep 3;34(36):4683-91.

Laron, Z. Interplay between heredity and environment in the recent explosion of type 1 childhood diabetes mellitus. Am J Med Genet. 2002;115(1):4-7.

Laurent, N., et al. Ketogenic diets in clinical psychology: examining the evidence and implications for practice. Front Psychol. 2024 Sep 26:15:1468894.

Lee, C., et al. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 2010 Feb 15;70(4):1564-72.

Lee, R.W.Y., et al. A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder. Physiol Behav. 2018 May 1:188:205-211.

Lefevre, F., et al. Ketogenic diet for the treatment of refractory epilepsy in children: A systematic review of efficacy. Pediatrics. 2000 Apr;105(4):E46.

Lennerz, B.S., et al. Management of Type 1 Diabetes With a Very Low-Carbohydrate Diet.
Pediatrics. 2018 Jun;141(6):e20173349.

Levi, J., et al. F as in fat how obesity threatens America’s future : 2012. Washington, D.C.: Trust for America’s Health; 2012.

Li, Q., et al. A Ketogenic Diet and the Treatment of Autism Spectrum Disorder. Front Pediatr. 2021 May 11:9:650624.

Liu, H., et al. Refined fructose and cancer. Expert Opin Ther Targets. 2011 Sep;15(9):1049-59.

Liu, S., et al. Poor glycaemic control is associated with increased risk of neurodevelopmental disorders in childhood-onset type 1 diabetes: a population-based cohort study. Diabetologia. 2021 Apr;64(4):767-777.

Longhitano, C., et al. The effects of ketogenic metabolic therapy on mental health and metabolic outcomes in schizophrenia and bipolar disorder: a randomized controlled clinical trial protocol. Front Nutr. 2024 Aug 21:11:1444483.

Lorenzi, M., et al. High glucose induces DNA damage in cultured human endothelial cells. J Clin Invest. 1986 Jan;77(1):322-5.

Ly, N.P., et al. Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol. 2011;127(5):1087-94; quiz 95-6.

Magrone, T., et al. Childhood obesity: immune response and nutritional approaches. Front Immunol. 2015;6:76.

Mazor-Aronovitch, A., et al. Dual diagnosis of type 1 diabetes mellitus and attention deficit hyperactivity disorder. Pediatr Diabetes. 2021 Jun;22(4):649-655.

McDonald, T.J.W., et al. Ketogenic Diets for Adult Neurological Disorders. Neurotherapeutics. 2018 Oct;15(4):1018-1031.

Mentzelou, M., et al. The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice. Nutrients. 2023 May 11;15(10):2270.

Mierau, S.B., et al. Metabolic interventions in Autism Spectrum Disorder. Neurobiol Dis. 2019 Dec:132:104544.

Minhas, P.S., et al. Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. Science. 2024 Aug 23;385(6711):eabm6131.

Mu, C., et al. Metabolic Framework for the Improvement of Autism Spectrum Disorders by a Modified Ketogenic Diet: A Pilot Study. J Proteome Res. 2020 Jan 3;19(1):382-390.

Murphy, P., et al. The antidepressant properties of the ketogenic diet. Biol Psychiatry. 2004 Dec 15;56(12):981-3.

Nguyen, T.T., et al. Type 3 Diabetes and Its Role Implications in Alzheimer's Disease. Int J Mol Sci. 2020 Apr 30;21(9):3165.

Noland, R.C., et al. Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem. 2009 Aug 21;284(34):22840-52.

Norwitz, N.G., et al. Ketogenic diet as a metabolic treatment for mental illness. Curr Opin Endocrinol Diabetes Obes. 2020 Oct;27(5):269-274.

Olivito, I., et al. Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T+ Itpr3tf/J mice. Exp Neurol. 2023 Aug:366:114432.

Omori, N.E., et al. Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders. Front Psychiatry. 2023 Apr 17:14:1142682.

Onodera, Y., et al. Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest. 2014 Jan;124(1):367-84.

Operta, F.F., et al. The Ketogenic Diet for the Treatment of Mood Disorders in Comorbidity With Epilepsy in Children and Adolescents. Front Pharmacol. 2020 Nov 24:11:578396.

Pacal, L., et al. Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus. Arch Physiol Biochem. 2011;117(4):222-30.

Pagoto, S.L., et al. Association between adult attention deficit/hyperactivity disorder and obesity in the US population. Obesity (Silver Spring). 2009 Mar;17(3):539-44.

Palmer, C.M. Ketogenic diet in the treatment of schizoaffective disorder: Two case studies. Schizophr Res. 2017 Nov:189:208-209.

Palmer, C.M., et al. The ketogenic diet and remission of psychotic symptoms in schizophrenia: Two case studies. Schizophr Res. 2019 Jun:208:439-440.

Paoli, A., et al. Ketogenic diet in neuromuscular and neurodegenerative diseases. Biomed Res Int. 2014:2014:474296.

Phelps, J.R., et al. The ketogenic diet for type II bipolar disorder. Neurocase. 2013;19(5):423-6.

Pietrzak, D., et al. The Therapeutic Role of Ketogenic Diet in Neurological Disorders. Nutrients. 2022 May 6;14(9):1952.

Pillinger, T., et al. Impaired Glucose Homeostasis in First-Episode Schizophrenia: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2017 Mar 1;74(3):261-269.

Power, R.A., et al. Carnitine revisited: potential use as adjunctive treatment in diabetes. Diabetologia. 2007 Apr;50(4):824-32.

Prins, M.L., et al. Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury. J Neurosci Res. 2005 Nov 1;82(3):413-20.

Pulgaron, E.R. Childhood obesity: a review of increased risk for physical and psychological comorbidities. Clin Ther. 2013;35(1):A18-32.

Pulsifer, M.B., et al. Effects of ketogenic diet on development and behavior: preliminary report of a prospective study. Dev Med Child Neurol. 2001 May;43(5):301-6.

Rector, R.S., et al. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J Hepatol. 2010 May;52(5):727-36.

Renteria, I., et al. [Factors affecting oxidative damage in obese children: an exploratory study]. Nutr Hosp. 2015;31(4):1499-503.

Robinette, L.M., et al. Fruit and vegetable intake is inversely associated with severity of inattention in a pediatric population with ADHD symptoms: the MADDY Study. Nutr Neurosci. 2023 Jun;26(6):572-581.

Rosa, J.S., et al. Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes. Pediatr Diabetes. 2011;12(5):464-72.

Salzer, H.M. Relative hypoglycemia as a cause of neuropsychiatric illness. J Natl Med Assoc. 1966;58(1):12-17.

Sanchez, A., et al. Role of sugars in human neutrophilic phagocytosis. Am J Clin Nutr. 1973 Nov;26(11):1180-4.

Sanchez, M., et al. Childhood obesity: a role for gut microbiota? Int J Environ Res Public Health. 2015;12(1):162-75. J Integr Complement Med. 2023 Feb;29(2):69-79.

Sanago, F., et al. Mind- and Body-Based Interventions Improve Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. J Integr Complement Med. 2023 Feb;29(2):69-79.

Saraga, M., et al. Ketogenic diet in bipolar disorder. Bipolar Disord. 2020 Nov;22(7):765.

Sarnyai, Z., et al. Ketogenic Therapy in Serious Mental Illness: Emerging Evidence. Int J Neuropsychopharmacol. 2020 Jul 29;23(7):434-439.

Schwalfenberg, G.K. The Importance of Magnesium in Clinical Healthcare. Scientifica (Cairo). 2017:2017:4179326.

Sethi, S., et al. The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review. J Psychiatr Brain Sci. 2022;7(5):e220009.

Seyfried, T.N. Cancer as a metabolic disease. Nutr Metab (Lond). 2010 Jan 27:7:7.

Seyfried, T.N. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 2014 Mar;35(3):515-27.

Seyfried, T.N., et al. Consideration of Ketogenic Metabolic Therapy as a Complementary or Alternative Approach for Managing Breast Cancer. Front Nutr. 2020 Mar 11:7:21.

Seyfried, T.N., et al. Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? Epilepsy Res. 2012 Jul;100(3):310-26.

Seyfried, T.N., et al. Metabolic management of brain cancer. Biochim Biophys Acta. 2011 Jun;1807(6):577-94.

Shen, W., et al. Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. J Cell Biochem. 2008 Jul 1;104(4):1232-43.

Shlomowitz, A., et al. Anxiety associated with self monitoring of capillary blood glucoseBritish Journal of Diabetes. 2014;14(2):60-63.

Smith, J., et al. Ketogenic diet restores aberrant cortical motor maps and excitation-to-inhibition imbalance in the BTBR mouse model of autism spectrum disorder. Behav Brain Res. 2016 May 1:304:67-70.

Smith, K.J., et al. Association of diabetes with anxiety: a systematic review and meta-analysisJ Psychosom Res. 2013;74(2):89-99.

Sreekumar, R., et al. Skeletal muscle mitochondrial dysfunction & diabetes. Indian J Med Res. 2007 Mar;125(3):399-410.

Stafstrom, C.E., et al. The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol. 2012 Apr 9:3:59.

Stewart, C.J., et al. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature. 2018 Oct;562(7728):583-588.

Tao, Y., et al. Ketogenic Diet: An Effective Treatment Approach for Neurodegenerative Diseases. Curr Neuropharmacol. 2022 Nov 15;20(12):2303-2319.

Tidman, M.M., et al. Effects of an low carbohydrate/healthy fat/ketogenic diet on biomarkers of health and symptoms, anxiety and depression in Parkinson's disease: a pilot study. Neurodegener Dis Manag. 2022 Apr;12(2):57-66.

Tinkum, K.L., et al. Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7148-54.

Townsend, L., et al. Brain glucose metabolism in schizophrenia: a systematic review and meta-analysis of 18FDG-PET studies in schizophrenia. Psychol Med. 2023 Aug;53(11):4880-4897.

Tun, H.M., et al. Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring. JAMA Pediatr. 2018 Apr 1;172(4):368-377.

Tuomi, T., et al. The many faces of diabetes: a disease with increasing heterogeneity. Lancet. 2014;383(9922):1084-94.

Vaarala, O. Is the origin of type 1 diabetes in the gut? Immunol Cell Biol. 2012;90(3):271-6.

Vaarala, O. Gut microbiota and type 1 diabetes. Rev Diabet Stud. 2012;9(4):251-9.

Vargas, D.D., et al. Effectiveness of nutritional interventions on behavioral symptomatology of autism spectrum disorder: a systematic review. Nutr Hosp. 2022 Dec 20;39(6):1378-1388.

Vatanen, T., et al. The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Nature. 2018 Oct;562(7728):589-594.

Verberne, A.J.M., et al. Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetesBr J Pharmacol. 2016;173(9):1425-1437.

Witkowski, M., et al. The artificial sweetener erythritol and cardiovascular event risk. Nat Med. 2023 Mar;29(3):710-718.

Xiang, A.H., et al. Maternal Gestational Diabetes Mellitus, Type 1 Diabetes, and Type 2 Diabetes During Pregnancy and Risk of ADHD in Offspring. Diabetes Care. 2018 Dec;41(12):2502-2508.

Xu, F., et al. Association of attention-deficit/hyperactivity disorder with diabetes mellitus in US adults. J Diabetes. 2021 Apr;13(4):299-306.

Yuan, J., et al. Regular use of proton pump inhibitors and risk of type 2 diabetes: results from three prospective cohort studies. Gut. 28 Sep 2020.

Zheng, P., et al. Gut microbiome in type 1 diabetes: A comprehensive review. Diabetes Metab Res Rev. 2018 Oct;34(7):e3043.

Zhou, H., et al. Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms. Front Endocrinol (Lausanne). 2020 Mar 24:11:125.