We will be interviewing Katie Reid PhD, Executive Director of Unblind My Mind, about glutamates and autism on Wednesday, June 23rd at 1:00pm Eastern. Sign up below to join us!
Glutamate is an amino acid that is also a neurotransmitter. It regulates norepinephrine, serotonin, dopamine and acetylcholine, which are other neurotransmitters that are also responsible for mood and behavior. It becomes more damaging when it is “free”, as is the case in processed foods.
In excess amounts, glutamate can be destructive to brain cells, as it is an excitotoxin, a term that was brought to fame by Russell Blaylock’s book, Excitotoxins: The Taste That Kills.
High free glutamates can be a confounding factor in conditions such as:
- Sensory Processing Disorder
- Learning disabilities
- PANDAS and PANS
- Bipolar disorders
- Anxiety disorders
Dr. Reid will tell us why symptoms of these disorders may disappear when eating a low-glutamate diet. She’ll guide us through what foods glutamates are hiding in and what symptoms they can produce. She’ll also be talking about the effects of excess calcium and EMFs with respect to glutamate. Join us!
About Katie Reid PhD
Dr. Katherine Reid is a biochemist and the founder of Unblind My Mind (UMM), a nonprofit 501(c)3 organization dedicated to improving health one bite at a time.
Because she is a biochemist, she researched brain chemistry and discovered that many of the foods she was feeding her daughter were causing her daughter’s autism symptoms. She discovered how free glumates in food can cause symptoms of autism, and her TEDx video Unblind My Mind: What Are We Eating? Dr. Katherine Reid at [email protected] has been viewed over 250,000 times.
In graduate school, she studied biochemistry and was a teaching assistant for Chemistry of Nutrition. From a scientific perspective, she appreciated the link between nutrition and vital biochemical functions. Her career has focused on protein chemistry mainly as it applies to developing protein therapeutics.
She has conducted her own scientific investigation, researching manufacturing processes used in foods, supplements, body products, and many over-the-counter medications. She unveiled that certain ingredients and additives in these products are associated with many chronic illnesses. UMM is dedicated to raising awareness of how these ingredients, abundant in our environment, impact our health. UMM’s vision is to create a community with greater understanding and heightened awareness of the foods we eat and their impact on our health.
UMM, guided by Dr. Reid, helps individuals, families, and groups implement healthy food choices, providing unique educational programs to this end. Many have told Dr. Reid that despite their training in the medical or nutrition field, they were never taught the information that she shared. You can find out more about her and her work at her website: https://unblindmymind.org/
This webinar is not a substitute for medical advice, treatment, diagnosis, or consultation with a medical professional. It is intended for general informational purposes only and should not be relied on to make determinations related to treatment of a medical condition. Epidemic Answers has not verified and does not guaranty the accuracy of the information provided in this webinar.
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Sources & References
Blaylock, R.L., et al. Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system. Surg Neurol Int. 2012;3:19
Bravo, J.A., et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5.
Breitenkamp, A.F., et al. Voltage-gated Calcium Channels and Autism Spectrum Disorders. Curr Mol Pharmacol. 2015;8(2):123-32.
Brown, M.S., et al. Increased glutamate concentration in the auditory cortex of persons with autism and first-degreer elatives: A(1)H-MR study. Autism Res. 2013;6(1):1–10.
Choudhury, P.R., et al. Glutamate mediated signaling in the pathophysiology of autism spectrum disorders. Pharmacol Biochem Behav 100(2012)841–849
Cocito, L., et al. GABA and phosphatidylserine in human photosensitivity: a pilot study. Epilepsy Res. 1994 Jan;17(1):49-53.
Coghlan, S., et al. GABA System Dysfunction in Autism and Related Disorders: From Synapse to Symptoms. Neurosci Biobehav Rev. 2012;36(9):2044–2055.
DeHavenon, A., et al. The Secret “Spice”: An Undetectable Toxic Cause of Seizure. Neurohospitalist. 2011 Oct; 1(4): 182–186.
Ding, H., et al. Molecular Pathogenesis of Anti-NMDAR Encephalitis. Biomed Res Int. 2015;2015:643409.
D’Souza, C.E., et al. GAD65 antibody-associated autoimmune epilepsy with unique independent bitemporal-onset ictal asystole. Epileptic Disord. 2018 Jun 1;20(3):204-208.
Eimerl, S., et al. Acute glutamate toxicity and its potentiation by serum albumin are determined by the Ca2+ concentration. Neurosci Lett. 130 (1991) 125–127
Fernell, E. Further studies of GABA and Glutamate imbalances in autism are important challenges for future research. Acta Paediatr. 2019 Feb;108(2):200-201.
Ford, T.C., et al. Psychosocial deficits across autism and schizotypal spectra are interactively modulated by excitatory and inhibitory neurotransmission. Autism. 2019 Jul 24:1362361319866030.
Gilliam, L.K., et al. Multiplicity of the antibody response to GAD65 in Type I diabetes. Clin Exp Immunol. 2004;138(2):337–341.
Hacohen, Y., et al. N‐methyl‐d‐aspartate (NMDA) receptor antibodies encephalitis mimicking an autistic regression. Dev Med Child Neurol. 2016 Oct;58(10):1092-4.
Hassel, B., et al. Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc. J Neurosci Res. 2014 Dec;92(12):1792-800.
Herbert, M.R, et al. Autism and EMF? Plausibility of a pathophysiological link–Part I. Pathophysiology 20.3 (2013): 191-209.
Herbert, M.R., et al. Autism and EMF? Plausibility of a pathophysiological link Part II. Pathophysiology 20.3 (2013): 211-234.
Huang, Y., et al. Pyridoxine Supplementation Improves the Activity of Recombinant Glutamate Decarboxylase and the Enzymatic Production of Gama-Aminobutyric Acid. PLoS One. 2016 Jul 20;11(7):e0157466.
Humphries, P., et al. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. 2008 Apr;62(4):451-62.
Kash, S.F., et al. Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A. 1997;94(25):14060–14065.
Khalifa, D., et al. Serum glutamate was elevated in children aged 3-10 years with autism spectrum disorders when they were compared with controls. Acta Paediatr. 2019 Feb;108(2):295-299.
Luo, P., et al. The role of glutamate receptors in traumatic brain injury: implications for postsynaptic density in pathophysiology. Brain Res Bull. 2011 Jul 15;85(6):313-20.
Manev, H., et al. Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death. Mol Pharmacol. 1989 Jul;36(1):106-12.
Naaijen, J., et al. Fronto-Striatal Glutamate in Autism Spectrum Disorder and Obsessive Compulsive Disorder. Neuropsychopharmacology. 2017 Nov;42(12):2456-2465.
Napolini, V., et al. The mitochondrial aspartate/glutamate carrier AGC1 and calcium homeostasis: Physiological links and abnormalities in autism. Mol Neurobiol. 44 (2011) 83–92.
Ou, D., et al. Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with Type I diabetes mellitus. Diabetologia. 2000 Jun;43(6):750-62.
Pall, M.L., The Autism Epidemic Is Caused by EMFs, Acting via Calcium Channels and Chemicals Acting via NMDA-Rs: Downstream Effects Cause Autism (conference presentation). 2015.
Pall, M.L., Electromagnetic fields act via activation of voltage‐gated calcium channels to produce beneficial or adverse effects. Journal of Cellular and Molecular Medicine 17.8 (2013): 958-965.
Palmieri, L., et al. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC. Mol Psychiatry. 2010 Jan;15(1):38-52.
Qi, J., et al. Enhanced susceptibility to stress and seizures in GAD65 deficient mice. PLoS One. 2018 Jan 29;13(1):e0191794.
Rojas, D.C. The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment. J Neural Transm (Vienna). 2014;121(8):891–905.
Rout, U.K., et al. Presence of GAD65 autoantibodies in the serum of children with autism or ADHD. Eur Child Adolesc Psychiatry. 2012 Mar;21(3):141-7.
Rowley, N.M., et al. Glutamate and GABA synthesis, release, transport and metabolism as targets for seizure control. Neurochem Int. 2012 Sep;61(4):546-58.
Sai, Y., et al. Clinical diagnosis and treatment of pediatric anti-N-methyl-D-aspartate receptor encephalitis: A single center retrospective study. Exp Ther Med. 2018 Aug;16(2):1442-1448.
Schauwecker, P.A. The effects of glycemic control on seizures and seizure-induced excitotoxic cell death. BMC Neurosci. 2012 Aug 6;13:94.
Silvestrin, R.B., et al. Animal model of autism induced by prenatal exposure to valproate: altered glutamate metabolism in the hippocampus. BrainRes. 1495 (2013) 52–60.
Tang, J., et al. Exposure to 900 MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats. Brain Res. 2015 Mar 19;1601:92-101.
Terpstra, M., et al. Changes in human brain glutamate concentration during hypoglycemia: insights into cerebral adaptations in hypoglycemia-associated autonomic failure in type 1 diabetes. J Cereb Blood Flow Metab. 2014;34(5):876–882.
Tzang, R.F., et al. Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related Therapy. Front Psychiatry. 2019 Jun 21;10:440.
Walls, A.B., et al. GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity. J Neurochem. 2010 Dec;115(6):1398-408.
Wang, Hsiuying. Anti-NMDA Receptor Encephalitis. Int J Mol Sci. 2017 Jan 18;18(1). pii: E193.
Watkins, J.C., et al. The glutamate story. Br J Pharmacol. 2006 Jan; 147(Suppl 1): S100–S108.
Yang, Y., et al. Role of metabotropic glutamate receptor 7 in autism spectrum disorders: A pilot study. Life Sci. 92 (2013) 149–153.
Zhang, Z., et al. Blood Glutamate Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. PLoS One. 2016 Jul 8;11(7):e0158688.
Adams, Mike.The Truth About Aspartame, MSG and Excitoxins. Truth Publishing, Inc., 2010.
Blaylock MD, Russell. Excitoxins: The Taste That Kills. Health Press, 1996.
Lambert, Beth, et al. Brain Under Attack: A Resource for Parents and Caregivers of Children with PANS, PANDAS and Autoimmune Encephalitis. Answers Publications, 2018.
Ross, Julia. The Mood Cure: The 4-Step Program to Take Charge of Your Emotions–Today. Penguin Life, 2003.
Scott, Trudy. The Antianxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood and End Cravings. New Harbinger Publications, 2011.
How to Increase GABA and Balance Glutamate: Article by Amy Yasko PhD, ND biochemist
MSG: Deadly Menace in Your Food: Article by Russell Blaylock MD, neurosurgeon
Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system: Peer-reviewed article by Russell Blaylock MD, neurosurgeon
Unblind My Mind: Dr. Reid’s website gives extensive explanation about the science, a TED talk by Dr. Reid and video tutorials to help parent’s discern appropriate foods in a local supermarket